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Treadmill exercise after social isolation increases the levels of NGF, BDNF, and synapsin I to induce survival of neurons in the hippocampus, and improves depression-like behavior
Young-Pyo Hong, Hyo-Chul Lee, Hyun-Tae Kim
Phys Act Nutr. 2015;19(1):11-18.   Published online March 31, 2015
DOI: https://doi.org/10.5717/jenb.2015.19.1.11

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Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner
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Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats
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SynCAM 1 improves survival of adult-born neurons by accelerating synapse maturation
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Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and “depression”-like behavior
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Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior
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Increases in mRNA levels for synapsin I but not synapsin II in the hippocampus of the rat kindling model of epilepsy
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