| Articles : The Effect of CoQ10 Supplementation on Plasma CoQ Concentration and Metabolic Response |
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| Abstract |
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The purpose of this study was to evaluate the effect of a CoQ10 supplement on the metabolic markers and CoQ concentration in well trained athletes. Our results showed lower ammonia and uric acid levels, both t the end of exercise and during recovery, after 4 weeks of CoQ10 administration compared to the levels of the control group. The exercise-test was repeated after 4 weeks. During this period 7 subjects (CoQ group) were supplemented CoQ10;the control group (n=7) were not supplemented. CoQ10 group were given 45㎎ doses of CoQ10 (Hanil Phama, Korea) twice per day for 4 weeks. Subjects were tested by an incremental work lad test until exhaustion on treadmill running. After ten minutes of warm up (speed 13㎞/hr), the subjects ran at an increasing speed (500 meters/every two minutes) until exhaustion. The exercise-test was repeated after 4 weeks. Our results suggest that oral administration of CoQ in the athletes increases blood level. CoQ group decrease the ammonia, uric acid, lactic acid, triglycerides. FFA and total cholesterol concentrations after supplementation, but control group were unchanged, he ammonia-lactic acid ratio as an index of energetic muscular system stress (metabolic waste production). At the end of exercise there was a significantly (P<.05) lower ratio in the CoQ group than control group. In conclusion, the present results clearly show that the coenzyme Q10 administration gave rise to elevated plasma CoQ concentration, while reduced ammonia-lactate ratio and muscular marker. We would suggest that further work is needed to elucidate the metabolic action of CoQ10 and its effect on physical performance. |
| Key Words:
CoQ10, supplementation, metabolic markers, muscular damage markers |
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