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Journal of Exercise Nutrition & Biochemistry 2003;7(1):35-40.
Articles : The effect of L-ornithine 2-oxoglutarate Administration on Plasma 2-oxglutarate, BCAA and Endurance Performance in Rats
Abstract
The purpose of this study was to investigate the effect pre-exercise administration of OKG (ornithine 2-oxoglutarate) on time to exhaustion during treadnill exercise in rats. Male sprague Dawley rats (n=56) were trained on a motor driven treadmill.RAts were injected into intraperitoneally with 2.5㎖ of placebo or OKG (0.5g/100g. b.W). 20min before performing 30 min of exercise (n=16) or exhaustion (n=16). In both cases, rats were sacrificed immediately following exercise, and blood was collected for a measurement of 2-oxoglutarate, glutamate, glutamine, Ammonia, BCAA, glycerol, glucose levels and exercise time. Following show us results. The plasma 2-oxoglutarate, glutamate, glutamine, ornithine concentrations of OKG group were increased than placebo group, and that was significantly (p<0.001). Plasma ammonia levels were similar at rest and exhaustion of exercise in both but lower after 30min on exercise in OKG (p<0.01). BCAA and glycerol levels of OKG group were increased than placebo group and that was significantly (p<0.001). Serum glucose concentration; In both group is no difference. The exercise period of OKG groups was longer by 15min, than that of Placebo groups, but there was not significantly. With the results we can conclude that during endurance exercise. OKG administration increase BCAA oxidation concentration by increase 2-oxoglutarate concentration, with helps to improve exercise performance.
Key Words: OKG, 2-oxglutarate, glutamate, glutamine, ornithine


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