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Journal of Exercise Nutrition & Biochemistry 2003;7(1):87-92.
Articles : The Effects of Hydroxy Citric Acid Supplementation and Swimming on Obesity and Lipid Metabolism in High-fat Diet Fed Rats
To evaluate the effects of hydroxy citric acid supplementation and swimming on body fat and lipid metabolism, we treated hydroxycitric acid supplementation (HF+HCA), exercise (HF+EX), or exercise plus hydroxy citric acid supplementation (HF+EX+HCA) in 8 weeks high-fat (HF) fed Sprague-Dawley male rats. The body weight and body fat mass were significantly decreased in both HF+HCA and HF+EX compared with HF rats despite that the food intake was not differed among the experimental groups. The decreasing effect of body weight by HCA was revealed after the day 32, which means that HCA has to be treated for relatively long time for weight reduction. Moreover, both HCA supplementation and EX reduced the plasma levels of glucose, triglycerides, and total cholesterol in HF fed rats. However, the carnitine palmitoyl transferase (CPT) 1 activity, a rate limiting enzyme in fat oxidation, was increased only in HF+EX rats. In summary, both hydroxy citric acid supplementation and exercise revealed anti-obesiry effects and their effects were additive. These results suggested that combination of bydroxy citric acid supplementation and exercise can be used as a modality of obesity treatment.
Key Words: Hydroxy Citric Acid, HCA, fat oxidation, CPTI, swimming


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