Articles : The Apolipoprotein CIII gene T2854G Polymorphism is Associated with Fasting and Postprandial Triacylglycerol Concentrations |
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Abstract |
This study was to investigate associations between the apolipoprotein CⅢ (apo CⅢ) polymorphism and triacylglycerlo (TAG) concentrations in fasting and postprandial plasma. Polymerase chain reaction followed by a restriction fragment length polymorphism was conducted to assess the allele frequency of the apo CⅢ T2854G variants in healthy and normolipidemic men (n=262_. Waist cireumference, body mas index (kg/m^(2)), fasting TAG, total cholesterol, highdensity lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured and compared among the genotypes. Compared to TT homozygotes or TG heterozygotes, GG homozygots had 22% higher fasting TAG concentrations, respectively (ps<0.05). A subgroup of 60 subjects (TT homozygotes=20. TG heterozygotes=22, GG homozygotes=18) were further invited to participate in a high fat-meal test to assess postprandial TAG concentrations among the genotypes. During the high fat-meal test, the GG homozygotes had 21% higher TAG concentrations than the TT homozygotes (p<0.05) and 22% higher TAG concentrations than the TG heterozygotes (p<0.05). In conclusion, this is the first study to report that the rare allele of the apo CⅢ T2854G variants is associated with elevated fasting and postprandial TAG concentrations in this study population. |
Key Words:
apo CIII gene polymorphism, triacylglycerol, postprandial period |
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