Articles : Effects of the Chronic Application of hGH and Ladder Climbing to the Aged Female SD Rats on their Morphological and Enzymological Properties Especially in FHL

Journal of Exercise Nutrition & Biochemistry 2004;8(1):37-42.

Abstract

The effects of hGH, resistance exercise, and the combination of them on morphological and enzymological properties especially of FHL in old female SD rats were investigated in this study. Thirsty one rats were divided into 4 groups including control; C (n=7), hGH administration; (n=8), resistance exercise; (n=8) and hGH plus resistance exercise; X (n=8). An hGH solution (somatropin, Saizen) was injected with 2.5 mg/kg/day dose to group G and X, and the same volume of saline was injected to group C and E. Resistance training was loaded by climbing 100 cm and 85 degrees ladder with certain weight at rat`s tail. And the load was gradually increased daily and periods based to the max. During eight weeks of treatment, through Muscle fiber type distribution, capillary density, citrate synthase enzyme activity and β-HAD, we can analyze morphological and enzymological properties especially in FHL.In the ability of the exercise their ability to climb ladder with some loads suspended their tails was improved continuously. In enzyme activities, but GH has basically lipid metabolism effect, E group has higher values than G and X group in β-HAD. Through these, resistance training has more effects than GH administration. Meanwhile, C group has lower value than E group in citrate synthase because our training was a high intensity resistance training, it would affect anaerobic metabolism.

Key Words: hGH, ladder climbing, FHL, muscle fiber type, CS, β-HAD