| Articles : Effect of Visceral Adipose Tissue on Atherogenic Lipoprotein-Lipids in Circulating Plasma |
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| Abstract |
O
bjective: Little is known about how visceral adiposity and apolipoprotein CⅢ in apo B-containing lipoproteins influence plasma triglyceride (TG) concentrations. The purpose of this study was to determine the relationships of visceral adiposity and apo CⅢ in apo B-containing lipoproteins with plasma TG concentrations in men and women. Procedure: A subgroup of 46 men (n=20, aged 29.1-33.4 yr) and women (n=26. aged 29-1 33.8 yr) were recruited from an ongoing population study at our institution. Anthropometric variables including weight, height, and waist circumference were measured using standard procedures, and body mass index was calculated (kg/m²). Visceral adipose tissue (VAT) was measured with a magnetic resonance imaging. Plasma apolipoproteins, lipids, glucose, and insulin were measured after an overnight fasting. Results: The men had significantly higher waist circumference, glucose, and TC/HDLC ratio than the women, while the women had significantly higher HDLC and apo Al than the men. Of particular, this is the first study to report that VAT and apo CⅢ in apo B-containing lipoproteins were independent predictors in determining plasma TG concentrations in Korean adults. Conclusion: Among the obesity indices measured in the current study. VAT and waist circumference were more consistently associated with the atherogenic lipoproteinlipids(i.e, triacylglycerol, apo CⅢs), fasting insulin and glucose. Consequently, the current study suggest that information on VAT and apo CⅢ in apo B-containing lipoproteins may provide additional information on the development of atherogenic lipid profiles and thereby atherosclerosis. |
| Key Words:
visceral adiposity, plasma triglyceride, apolipoprotein C-3 |
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