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Journal of Exercise Nutrition & Biochemistry 2008;12(1):45-52.
Effect of Exercise and Carnitine Supplementation on Blood Biochemical Components and Long Chain Fatty Acid Oxidation of Skeletal Muscles in Rats
The purpose of this study was to investigate the effects of chronic L-carnitine treatment on plasma lipids and skeletal muscle fat oxidation in rats. Animals (n=21) were divided into three groups: Control group (Con, n=7), carmitine treated group (CT, n=14) and carnitine plus exercise treated group; (CTE, n=14). Diet and exercise were treated for 6weeks. Compared with those in other groups, body weight and visceral fat weight were significantly lower in CTE groups than CON groups (p<.05). But there was no difference in food intake among each groups. Also, Plasma glucose, total-cholesterol and LDL-cholesterol concentration were significantly lower than CTE groups than CON groups (p<.05). However, The levels of HDL-cholesterol, triglyceride and free fatty acid were no difference among each groups. On the other hand, Long-chan fatty acid oxidation (LCFA) in red gestrocnemius were significantly higher in CET groups than in CON and CT groups but, white gestrocenemius were no difference each experimental groups. In conclusion, this study demonstrated that exercise and carnitine supplementation for 6 weeks have the beneficial effects on energy metabolism activity and fat oxidation facilitation by decreased plasma lipid in rats.
Key Words: exercise, carnitine, Long chain fatty acid oxidation


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