Influence of Treadmill Exercise Intensity on Neurological Recovery and Apoptosis in Rat Models of Focal Cerebral Ischemia

Journal of Exercise Nutrition & Biochemistry 2009;13(4):235-241.

Abstract

The study was designed to evaluate the effect of two different treadmill exercise intensity in focal cerebral ischemia model. thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups. Normal group(n = 8), ischemic brain injury group(n = 8), experimental group I has II been lower-intensity exercise with ischemic brain injury (n = 8), experimental group has been moderate-intensity exercise with ischemic brain injury(n = 8). The statistical analysis was evaluated by ANOVA for repeated measure. Each group has been examined by test as follow, neurological motor behavioral test, cognitive motor behavior test and histological test. Neurological motor behavior tests consisted of postural reflex test and beam walking test. In the creasyl violet staining and TUNEL staining were used. From these results the following conclusions obtained. The tests for motor function recovery change had significantly increased in the experimental groups as compared with control group. In order to determine whether the increase in cell proliferation caused by treadmill exercise intensity could be explained by changes in the level of the apoptotic protein. These results suggest that lower intensity exercise has good effects on motor function recovery after ischemic brain injury.

Key Words: apoptosis, cerebral ischemia, and exercise intensity