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Phys Act Nutr > Volume 25(2); 2021 > Article
Physical Activity and Nutrition 2021;25(2):33-37.
DOI:    Published online June 30, 2021.
The effects of royal jelly protein on bone mineral density and strength in ovariectomized female rats
Satoshi Hattori, Naomi Omi
Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan
Correspondence:  Naomi Omi, Tel: +81-29-853-6319, Fax: +81-29-853-6507, 
Received: 12 June 2021   • Revised: 29 June 2021   • Accepted: 29 June 2021
*Satoshi Hattori and Naomi Omi contributed equally to this study as co-first authors.
Sex hormones deficiency leads to dramatically bone loss in particular postmenopausal women. Royal jelly has anti-osteoporosis effect due to maintain bone volume in that condition. We hypothesized that royal jelly protein (RJP, a latent residue after extracting royal jelly) also prevents bone deficient in ovariectomized (OVX) female rats, the animal model of postmenopausal women.
Female Sprague-Dawley rats (n = 30, 6 weeks age old) were sham operated (Sham; sham operated group, n = 7), OVX control group (OC, n = 7), OVX with low RJP intake group (ORL, n = 8), and OVX with high RJP intake group (ORH, n = 8) during 8 weeks experimental periods. In the end point of this experiment, the bone samples (lumbar spine, tibia, and femur) were surgically removed under anesthesia. These bone samples were evaluated bone mineral density (BMD) and bone strength.
BMD of lumbar spine in RJP intake groups (ORL, ORH) were higher than that in OC group (p < 0.05 and p < 0.01) in RJP intake volume dependent manner. BMD of tibial proximal metaphysis and diaphysis in RJP intake groups were also higher than these in OC group (p < 0.01 and p < 0.01 / p < 0.05 and p < 0.001). In addition, breaking force of femur in RJP intake groups were significantly increase compared with that in OC group (p < 0.001 respectively).
These findings indicate that RJP contribute to prevent sex hormone related bone abnormality
Key Words: royal jelly protein, BMD, bone strength, OVX, osteoporosis, postmenopausal women


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