Articles : The Effects of Clenbuterol Administration and Endurance Exercise on Plasma Leptin Responses in S-D Rats

Journal of Exercise Nutrition & Biochemistry 2002;6(2):121-126.

Abstract

This study aimed to see clenbuterol(β_2-adrenergic agonist) administration, exercise training, and the combination of these on plasma leptin responses and endurance exercise performance were investigated. Forty male Sprague-Dawely rats were randomly assigned to one of four treatment groups : The whole rats eating 30% Hight-fat diet control(CON; n=10), clenbuterol(CL; n=10), exercise trained(EX; n=10), or clenbuterol/Exercise trained(CL+EX; n=10). The exercise protocol consist of running on motor-driven treadmill up an 8% grade, 27 m/min, 1 hr/day, 5 days/wk for 2 weeks. Clenbuterol were intubated with 2 ㎎/㎏ body wt/day dissolved in deionized water, Clenbuterol did not change body weight compared with control groups. Exercise training and clenbuterol administration significantly decreased plasma leptin, glucose, and insulin hormone. There was correlation significantly between insulin and leptin. Exercise training groups significantly decreased blood TC, HDL-C. clenbuterol administration significantly increased plasma LDL-C. CL and CL+EX groups significantly decreased endurance running time compared with EX group. The results of the current study indicate that the effects of clenbuterol administration are the same as the effects of exercise training in leptin levele, The combined effects of these two treatments in decreasing the leptin level was additive.