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Journal of Exercise Nutrition & Biochemistry 2004;8(2):137-146.
Articles : Effect of Isoflavone and Exercise on Blood Lipids in Growing Rats
The purpose of this study was to examine the effects of isoflavone and exercise on blood lipids in growing rats. Twenty female, Sprague-Dawley female rats (age 28 days) were assigned to four groups, that underwent 9 weeks of experimental treatment. Animals were assigned to one of two exercise treatments (swimming or sedentary). The exercise and nonexercise group were fed a diet containing casein or casein with isoflavone. The exercise group swam 30 minutes three days per week during the 9-week study period. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks. Serum total cholesterol, LDL-cholesterol, and HDL-cholesterol levels were not significantly altered with exercise nor isoflavones consumption. However, a trend toward lowered cholesterol level was observed after exercise or isoflavone consumption, but results did not attain statistical significance. Although the effects were small, it is possible that isoflavone may contribute to a lower risk of coronary heart disease if consumed over many years in conjunction with exercise. And the exercise group appears to have a significantly lower triglyceride compared to nonexercise group. And exercise combined with isoflavone group had significantly lower triglyceride compared to exercise with casein group. The results indicate that exercise combined with isoflavone had a positive influence on blood triglyceride. It can be concluded that exercise combined with an isoflavone is most beneficial for control blood triglyceride in young growing rats.
Key Words: isoflavone, exercise, triglyceride, growing female rat


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